Affordable Access

Influence of oestrogen receptor alpha and beta on the immune system in aged female mice.

Authors
  • Islander, U
  • Erlandsson, M C
  • Hasséus, B
  • Jonsson, C A
  • Ohlsson, C
  • Gustafsson, J-A
  • Dahlgren, U
  • Carlsten, H
Type
Published Article
Journal
Immunology
Publication Date
Sep 01, 2003
Volume
110
Issue
1
Pages
149–157
Identifiers
PMID: 12941152
Source
Medline
License
Unknown

Abstract

Oestrogen has a dichotomous effect on the immune system. T and B lymphopoiesis in thymus and bone marrow is suppressed, whereas antibody production is stimulated by oestrogen. In this study the importance of the oestrogen receptors (ER) ER-alpha and ER-beta in the aged immune system was investigated in 18 months old-wild type (WT), ER-alpha (ERKO), ER-beta (BERKO) and double ER-alpha and ER-beta (DERKO) knock-out mice, and compared with 4 months old WT mice. Cell phenotypes in bone marrow, spleen and thymus, and the frequency of immunoglobulin (Ig) spot forming cells (SFC) were determined. We show here that the 17-beta-oestradiol (E2)-induced downregulation of B lymphopoietic cells in bone marrow of young ovariectomized mice can be mediated through both ER-alpha and ER-beta. However, only ER-alpha is required for the age-related increased frequency of immunoglobulin M (IgM) SFC in the bone marrow, as well as for the increased production of interleukin-10 (IL-10) from cultured splenocytes in aged mice. Furthermore, increased age in WT mice resulted in lower levels of both pro- and pre-B cells but increased frequency of IgM SFC in the bone marrow, as well as increased frequency of both IgM and IgA SFC in the spleen. Results from this study provide valuable information regarding the specific functions of ER-alpha and ER-beta in the aged immune system.

Report this publication

Statistics

Seen <100 times