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The influence of normobaric hyperoxia on lung surfactant phospholipids in rats.

Authors
  • Ledwozyw, A
  • Borowicz, B
Type
Published Article
Journal
Archivum veterinarium Polonicum / Polish Academy of Sciences, Committee of Veterinary Sciences
Publication Date
Jan 01, 1992
Volume
32
Issue
3-4
Pages
127–133
Identifiers
PMID: 1339568
Source
Medline
License
Unknown

Abstract

The influence of 12-, 24- and 48-h normobaric hyperoxia on phospholipid composition of lung surfactant in rats was investigated. Both in surfactant isolated from bronchoalveolar lavage and in surfactant isolated from lung tissue after 12 h breathing of pure oxygen, a decrease in both phosphatidylcholine (particularly in disaturated ones) and phosphatidylglycerol content was observed. This decrease was compensated with concomitant increase in lysophosphoglyceride content. A drop in total phospholipid level in surfactant of oxygen-exposed rats was observed. These data suggest that normobaric hyperoxia causes a substantial changes in lung surfactant composition and type II pneumocyte metabolism.

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