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Influence of Morphine and Naloxone on Pain Modulation in Rheumatoid Arthritis, Chronic Fatigue Syndrome/Fibromyalgia, and Controls: A Double-Blind, Randomized, Placebo-Controlled, Cross-Over Study.

Authors
  • Hermans, Linda1, 2
  • Nijs, Jo2, 3, 4
  • Calders, Patrick1
  • De Clerck, Luc5
  • Moorkens, Greta6
  • Hans, Guy7
  • Grosemans, Sofie7
  • Roman De Mettelinge, Tine1
  • Tuynman, Joanna8
  • Meeus, Mira1, 2, 8
  • 1 Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. , (Belgium)
  • 2 Pain in Motion International Research Group, Vrije Universiteit Brussel, Brussels, Belgium. , (Belgium)
  • 3 Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. , (Belgium)
  • 4 Department of Rehabilitation and Physiotherapy, University Hospital Brussels, Brussels, Belgium. , (Belgium)
  • 5 Department of Immunology, Allergy and Rheumatology, University of Antwerp, Antwerp, Belgium. , (Belgium)
  • 6 Department of Internal Medicine, University Hospital Antwerp, Antwerp, Belgium. , (Belgium)
  • 7 Multidisciplinary Pain Center, University Hospital Antwerp, Antwerp, Belgium. , (Belgium)
  • 8 Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. , (Belgium)
Type
Published Article
Journal
Pain practice : the official journal of World Institute of Pain
Publication Date
Jul 19, 2017
Identifiers
DOI: 10.1111/papr.12613
PMID: 28722815
Source
Medline
Keywords
License
Unknown

Abstract

This study revealed anti-hyperalgesia effects of morphine in CFS/FM and RA patients. Nevertheless, these effects were comparable to placebo. Besides, neither morphine nor naloxone influenced deep tissue pain, temporal summation or CPM. Therefore, these results suggest that the opioid system is not dominant in (enhanced) bottom-up sensitization (temporal summation) or (impaired) endogenous pain inhibition (CPM) in patients with CFS/FM or RA.

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