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Influence of medium polarity on the photosensitizing properties of hematoporphyrin and hematoporphyrin derivative (Photofrin II).

Authors
  • Shopova, M
  • Gantchev, T
Type
Published Article
Journal
Journal of Photochemistry and Photobiology B Biology
Publisher
Elsevier
Publication Date
Nov 01, 1988
Volume
2
Issue
3
Pages
365–371
Identifiers
PMID: 2853216
Source
Medline
License
Unknown

Abstract

The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes. Thus, the solvent-induced breakdown of the aggregated components of Photofrin II appears to determine the photosensitizing efficiency of this porphyrin.

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