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[Influence of irradiation on the risk of HIV virus transmission by bone allograft].

Authors
  • Hernigou, P
  • Marinello, G
  • Dormont, D
Type
Published Article
Journal
Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
Publication Date
Oct 01, 1998
Volume
84
Issue
6
Pages
493–500
Identifiers
PMID: 9846322
Source
Medline
License
Unknown

Abstract

Considering a mean level of contamination of 30 TCID50 per milliliter of plasma during the asympomatic phase of infection, the reduction of the transmission risk of HIV by a femoral head allograft was calculated in the best case to be only 5 per cent when performed at 25 kilograys. Irradiation cannot be considered as a process able to achieve sterility of the graft and has to be associated to an extensive screening. However irradiation associated with appropriate screening of donors decreases the risk of transmission of the disease under one out of one million in femoral allograft implantation.

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