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The influence of intravascular volume expansion on cerebral blood flow and blood volume in normal rats.

Authors
Type
Published Article
Journal
Anesthesiology
Publication Date
Volume
78
Issue
5
Pages
945–953
Identifiers
PMID: 8489067
Source
Medline
License
Unknown

Abstract

In normal brain, CBF does not change during volume expansion, in spite of an increase in CO. This contradicts earlier studies, the results of which indicate an independent role for cardiac output in CBF control. Cerebral blood volume increased in proportion to CVP, suggesting simple passive venous distention. Whether this could increase ICP and compromise cerebral perfusion remains unclear.

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