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The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases.

Authors
  • Linder, C C
Type
Published Article
Journal
Lab animal
Publication Date
May 01, 2001
Volume
30
Issue
5
Pages
34–39
Identifiers
PMID: 11385732
Source
Medline
License
Unknown

Abstract

In recent years, the use of genetically altered mice as models of complex human disease has revolutionized biomedical research into the genetics of disease pathogenesis and potential therapeutic interventions. Whether a mouse expresses a spontaneous or induced mutation, it is critical to remember that the observed phenotype is not always the direct result of the genetic alteration. The author points out the importance of considering the genetic background of the strain used to create these important models.

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