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Influence of gastric acidity on the bioavailability of digoxin.

Authors
  • Cohen, A F
  • Kroon, R
  • Schoemaker, R
  • Hoogkamer, H
  • van Vliet, A
Type
Published Article
Journal
Annals of Internal Medicine
Publisher
American College of Physicians
Publication Date
Oct 01, 1991
Volume
115
Issue
7
Pages
540–545
Identifiers
PMID: 1883123
Source
Medline
License
Unknown

Abstract

Our data suggest that gastric acidity causes the breakdown of digoxin to products that cross-react in the assay (EIA) that is commonly used clinically. In patients with reduced gastric acidity, increased plasma concentrations of unchanged digoxin may not be detected because of limitations of the EIA, which may invalidate the quantitative use of the plasma digoxin concentration as a predictor of digoxin toxicity. Omeprazole, and presumably other gastric-acid inhibitors, may increase the bioavailability of unchanged digoxin.

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