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The influence of field size and other treatment factors on pulmonary toxicity following hyperfractionated irradiation for inoperable non-small cell lung cancer (NSCLC)--analysis of a Radiation Therapy Oncology Group (RTOG) protocol.

Authors
  • Byhardt, R W
  • Martin, L
  • Pajak, T F
  • Shin, K H
  • Emami, B
  • Cox, J D
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Oct 20, 1993
Volume
27
Issue
3
Pages
537–544
Identifiers
PMID: 8226146
Source
Medline
License
Unknown

Abstract

For nonsmall cell lung cancer treated with hyperfractionated irradiation, the risk of overall pulmonary toxicity was increased for patients treated with field sizes in excess of protocol specified margins of tumor coverage in comparison to patients treated with protocol specified margins. This effect was seen only when the area of lung treated beyond protocol margins exceeded 35 cm2 and when the overall field size was below 180 cm2.

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