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The influence of Eruca sativa (Arugula) on pharmacokinetics of Sildenafil in rats.

Authors
  • Mallah, Eyad1
  • Saleh, Soadad1
  • Rayyan, Walid Abu1
  • Dayyih, Wael Abu1
  • Elhajji, Feras Darwish2
  • Mima, Mohammed1
  • Awad, Riad1
  • Arafat, Tawfiq1
  • 1 Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan. , (Jordan)
  • 2 Faculty of Pharmacy and Medical Sciences, Applied Science University, Amman, Jordan. , (Jordan)
Type
Published Article
Journal
Neuro endocrinology letters
Publication Date
Aug 05, 2017
Volume
38
Issue
4
Pages
295–300
Identifiers
PMID: 28871716
Source
Medline
License
Unknown

Abstract

Pre-administration of Eruca sativa has increased Sildenafil Cmax from 226.72 to 345.25 ng/ml, (p<0.05). In addition, the AUC of Sildenafil has significantly increased when it was pre-administered with Eruca sativa (550.59 vs. 916.48 ng/ml*hr). Our findings suggest that co-administration of Eruca sativa with Sildenafil enhances the pharmacokinetics of Sildenafil in rats plasma.

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