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Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit.

Authors
  • Pritchard, K A Jr
  • Karpen, C W
  • Merola, A J
  • Panganamala, R V
Type
Published Article
Journal
Prostaglandins, leukotrienes, and medicine
Publication Date
Oct 01, 1982
Volume
9
Issue
4
Pages
373–378
Identifiers
PMID: 6757965
Source
Medline
License
Unknown

Abstract

Rabbits were maintained on vitamin E-deficient and vitamin E-supplemented diets. Thrombin- and collagen-induced thromboxane A2 production were significantly elevated in vitamin E-deficient platelets. Conversion of arachidonic acid to platelet thromboxane A2 was unchanged between the two groups of animals. Prostacyclin I2 production in the aortas from vitamin E-deficient rabbits was significantly elevated.

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