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The influence of crude cobra venom on electrolyte levels and Na+, K+ ATPase activity in erythrocytes liver and heart cells.

Authors
  • Ansari, A F
  • Shaikh, D M
  • Seehar, G M
  • Yakoob, M
  • Jamali, A G
  • Jokhio, R
Type
Published Article
Journal
Pakistan journal of pharmaceutical sciences
Publication Date
Jul 01, 1989
Volume
2
Issue
2
Pages
19–27
Identifiers
PMID: 16414643
Source
Medline
License
Unknown

Abstract

The present study focuses on the in vitro interaction between snake venom and electrolytes and Na+, K+-stimulated ATPase system in number of tissues from humans and animals. The venom produced a change in the resting cellular sodium and potassium levels in all the tissues tested. When compared, only human cancerous tissue showed apparent fall in sodium and a rise in potassium, while no significant change occurred in normal. The effect of snake venom (25 microg/ml) on sodium pump activity, a transport enzyme, was assessed in normal tissues. Human erythrocyte membrane pump was significantly inhibited than-rabbit heart and liver tissue. With subsequent increase of dose no further change took place in these cells. A non significant and comparable stimulation in the enzyme activity was seen with rabbit heart and liver. These findings demonstrate that human erythrocytes are more sensitive towards the venom and secondly that venom might potentiate its cellular function by modifying the sodium pump activity.

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