Affordable Access

[Influence of calcium and phosphate ions on the adsorption rate of alkaline phosphatase and some of serum proteins on the hydroxyapatite].

Authors
  • Zhitkov, M Yu
  • Orlov, A A
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 2014
Issue
3
Pages
63–66
Identifiers
PMID: 25536793
Source
Medline
License
Unknown

Abstract

Calcium ions accelerate selective adsorption of AP on HAP and phosphate ions inhibit it. Since the biological function of AP is in the synthesis of phosphate ions from organic phosphates, enzyme activity contributes to its adsorption on mineralized tissues HAP, which can be associated with the peculiarities of the action of the enzyme adsorbed compared with dissolved. Apparently, the selective adsorption of enzymes and signaling molecules in the extracellular matrix to produce the microenvironment necessary for cell differentiation and function of tissue. Sorbate composition determines the type of cell differentiation, which, in turn, determines the properties of the synthesized matrix. Thereby circuiting occurs a feedback loop, to maintain homeostasis of tissues. These results can be used to develop a biomimetic material for medicine as well as the fabrication of multilayer coatings with desired properties by means of controlled speed by selectively depositing colloidal particles (nanoparticles). In the case of anisotropic particles the layers it is possible to obtain particles not only one type, but also with their desired orientation in each layer of particles by creating localized sorbent binding sites.

Report this publication

Statistics

Seen <100 times