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The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection.

Authors
Type
Published Article
Journal
Journal of molecular medicine (Berlin, Germany)
Publication Date
Volume
76
Issue
10
Pages
699–708
Identifiers
PMID: 9766848
Source
Medline
License
Unknown

Abstract

The propensity of HIV-1 for genetic variation, a consequence of error-prone reverse transcription combined with high rates of replication, is thought to contribute to the establishment of persistent infection in the host despite the presence of a vigorous antiviral immune response. Protective immunity to viruses is mediated primarily by cytotoxic T lymphocytes, which recognize viral peptides of 8-11 amino acids bound to major histocompatibility complex class I molecules on the surface of infected cells. In this review we examine the mechanisms by which mutation within peptide antigen-encoding regions of the viral genome enables HIV-1 to evade recognition by virus-specific cytotoxic T lymphocytes. The discussion is relevant to other genetically unstable viruses and more generally to intracellular pathogens of variable antigenicity.

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