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[Influence of antidepressants on the convulsive action of corazole and strychnine].

Authors
  • Chugunov, V V
Type
Published Article
Journal
Farmakologiia i toksikologiia
Publication Date
Jan 01, 1976
Volume
39
Issue
6
Pages
658–662
Identifiers
PMID: 1030667
Source
Medline
License
Unknown

Abstract

The influence of 10 antidepressants on an experimentally induced convulsive syndrome in mice was studied. It was found that, as concerns their ability to have an effect on DL50 of metrasol, the depressants may be classified into drugs protecting mice against the action of metrasol (melipramine, amitryptiline, chlorprothixen and phthoracizine), those potentiating the effect of metrasol (insidon, phrenolon, iproniazide, nuredal) and drugs producing no essential effect on DL50 of metrasol (desipramine, sonapax). All of the above drugs had an effect of decreasing the mean lethal dose of strychnine.

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