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Influence of anesthetics on Alzheimer's disease: biophysical, animal model, and clinical reports.

Authors
  • Silverstein, Jeffrey H
Type
Published Article
Journal
Journal of Alzheimer s Disease
Publisher
IOS Press
Publication Date
2014
Volume
40
Issue
4
Pages
839–848
Identifiers
DOI: 10.3233/JAD-130815
PMID: 24577477
Source
Medline
Keywords
License
Unknown

Abstract

Since the finding in the 1880 s that elderly patients may experience cognitive decline following surgery, the search for an understanding of this phenomenon has been underway. In the last decade, evidence from biophysical (light scattering and nuclear magnetic resonance), in vitro, in vivo animal studies, retrospective evaluations of human registries, and recently prospective randomized trials have explored the idea that various anesthetic agents play a role in this phenomenon by interacting with the biochemical mechanisms that are also responsible for the development of Alzheimer's disease. In the current review, we examine the evidence available and conclude that there is significant evidence to suggest an important role for this mechanism.

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