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The influence of Andiamina (hexobendine) on the histochemical reaction in the aorta wall of experimental animals.

Authors
  • Królikowska-Prasał, I
Type
Published Article
Journal
Acta Histochemica
Publisher
Elsevier
Publication Date
Jan 01, 1979
Volume
65
Issue
1
Pages
75–81
Identifiers
PMID: 118627
Source
Medline
License
Unknown

Abstract

The research was carried out on albino rats. The animals in the experimental group were given Andiamina (Hexobendine) in a dose of 40 mg/kg for a period of 7 days in the group I and 21 days in the group II. The results have pointed out that changes in the activity of the studied enzymes occurred especially after 21 days of Hexobendine administration. First of all, it caused a decrease in lactic and glucose-6-phosphate dehydrogenase activities and to lesser degree, it influenced the activities of iso-citric dehydrogenase and NAD and NADP tetrazole reductases. At the same time, reaction to succinic dehydrogenase indicated an increase in the enzymatic activity.

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