Affordable Access

Access to the full text

The Influence of the Acyl Chain on the Transdermal Penetration-Enhancing Effect of Synthetic Phytoceramides

Authors
  • Veryser, Lieselotte
  • Boonen, Jente
  • Taevernier, Lien
  • Guillaume, Joren
  • Risseeuw, Martijn
  • Shah, Syed Nisar Hussain
  • Roche, Nathalie
  • Van Calenbergh, Serge
  • De Spiegeleer, Bart
Type
Published Article
Journal
Skin Pharmacology and Physiology
Publisher
S. Karger AG
Publication Date
Dec 16, 2014
Volume
28
Issue
3
Pages
124–136
Identifiers
DOI: 10.1159/000365730
PMID: 25531080
Source
Karger
Keywords
License
Green
External links

Abstract

Background/Aims: The skin has become very attractive as a route for drug administration. Optimization of topical drug formulations by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. Methods: In this paper, the skin penetration effect of phytosphingosine and 9 derived phytoceramides (PCERs) on 3 transdermal model drugs (i.e. caffeine, testosterone, ibuprofen) was investigated via Franz diffusion cell experiments using split-thickness human skin. Azone was included as a positive control. Results: The main finding in our study was that the PCERs exerted a compound-dependent penetration-enhancing effect. Some of the investigated PCERs exhibited a penetration-enhancing ratio of more than 2 (mean ± SE): for caffeine PCER1 (2.48 ± 0.44), PCER2 (2.75 ± 0.74), PCER3 (2.62 ± 0.93) and PCER6 (2.70 ± 0.45) and for testosterone PCER1 (2.08 ± 0.56), PCER2 (2.56 ± 0.13), PCER3 (3.48), PCER4 (2.53), PCER5 (2.04 ± 0.14), PCER6 (2.05 ± 0.48) and PCER10 (4.84 ± 0.79), but none of them had an influence on ibuprofen. Conclusion: The investigated PCERs exhibited a penetration-enhancing effect on caffeine and testosterone but not on ibuprofen.

Report this publication

Statistics

Seen <100 times