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[Influence of the activation of the immune system cells on the parameters of lipid metabolism in macrophages].

Authors
  • Dushkin, M I
  • Perminova, O M
  • Safina, A F
  • Vol'skiĭ, N N
  • Shvarts, Ia Sh
  • Kozlov, V A
Type
Published Article
Journal
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
Publication Date
Jan 01, 2004
Issue
6
Pages
52–56
Identifiers
PMID: 15636141
Source
Medline
License
Unknown

Abstract

The influence of tumor necrosis factor a (TNF-alpha) and media, conditioned by activated macrophages and lymphocytes and containing a complex of biologically active compounds (including cytokines), on the parameters of lipid metabolism in macrophages was studied. The addition of recombinant TNF-alpha and immunocompetent cell-conditioned media to mouse peritoneal macrophages culture stimulated labelled oleate incorporation into cholesterol esters and triglycerides, as well as labelled glycerine incorporation into cholesterol esters, but inhibited labelled cholesterol incorporation into cholesterol esters. One of the mechanisms of the influence of activated immunocompetent cells on cholesterol metabolism in macrophages was, supposedly, the stimulation of sphigmomyelinase activity by a complex of anti-inflammatory cytokines produced by these cells on their activation.

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