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Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion.

Authors
  • Gensler, H
  • Bowden, G T
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Feb 01, 1984
Volume
22
Issue
1
Pages
71–75
Identifiers
PMID: 6321021
Source
Medline
License
Unknown

Abstract

Tumor initiation in CD-1 mice by benzo[a]pyrene (BaP) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was unaffected by topical pretreatment with 13-cis-retinoic acid (13-cis-RA). Likewise, anthralin-induced tumor promotion in SENCAR mice was unaffected by pretreatment with 13-cis-RA. These results suggest that the action of retinoids in preventing either tumor initiation or promotion is very carcinogen or cocarcinogen specific.

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