Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion.
- Published Article
- Publication Date
Feb 01, 1984
Tumor initiation in CD-1 mice by benzo[a]pyrene (BaP) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was unaffected by topical pretreatment with 13-cis-retinoic acid (13-cis-RA). Likewise, anthralin-induced tumor promotion in SENCAR mice was unaffected by pretreatment with 13-cis-RA. These results suggest that the action of retinoids in preventing either tumor initiation or promotion is very carcinogen or cocarcinogen specific.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6321021