Affordable Access

deepdyve-link
Publisher Website

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Authors
  • Bosteels, Cedric1, 2
  • Neyt, Katrijn1, 2
  • Vanheerswynghels, Manon1, 2
  • van Helden, Mary J.1, 2
  • Sichien, Dorine1, 2
  • Debeuf, Nincy1, 2
  • De Prijck, Sofie1, 2
  • Bosteels, Victor2, 3
  • Vandamme, Niels4, 5
  • Martens, Liesbet4, 6
  • Saeys, Yvan4, 5
  • Louagie, Els7
  • Lesage, Manon7
  • Williams, David L.8
  • Tang, Shiau-Choot9
  • Mayer, Johannes U.9
  • Ronchese, Franca9
  • Scott, Charlotte L.1, 6
  • Hammad, Hamida1, 2, 10
  • Guilliams, Martin1, 6
  • And 1 more
  • 1 Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent 9052, Belgium
  • 2 Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium
  • 3 Laboratory of ER Stress and Inflammation, VIB-UGent Center for Inflammation Research, Ghent 9052, Belgium
  • 4 Data Mining and Modeling for Biomedicine Group, VIB-UGent Center for Inflammation Research, Ghent 9052, Belgium
  • 5 Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent 9000, Belgium
  • 6 Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium
  • 7 Argenx BV, Ghent 9052, Belgium
  • 8 Department of Surgery and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
  • 9 Malaghan Institute of Medical Research, Wellington 6012, New Zealand
  • 10 Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam 3015 GJ, the Netherlands
Type
Published Article
Journal
Immunity
Publication Date
May 08, 2020
Volume
52
Issue
6
Pages
1039–1056
Identifiers
DOI: 10.1016/j.immuni.2020.04.005
PMID: 32392463
PMCID: PMC7207120
Source
PubMed Central
Keywords
License
Unknown

Abstract

The dichotomy between type 1 and 2 conventional DCs under steady-state conditions is well defined. Bosteels et al. demonstrate that, upon inflammation, cDC2s acquire a hybrid inf-cDC2 phenotype, sharing phenotype, gene expression, and function with cDC1s and monocyte-derived cells, to optimally boost CD4 and CD8 immunity via Fc receptors.

Report this publication

Statistics

Seen <100 times