Affordable Access

[Inflammatory response mediators in newborns and infants with congenital heart diseases during surgical treatment under extracorporeal circulation].

Authors
  • Bokeriia, L A
  • Samuilova, D Sh
  • Averina, T B
  • Samsonova, N N
  • Neshkova, E A
  • Fokina, N S
  • Gurova, M M
Type
Published Article
Journal
Anesteziologiia i reanimatologiia
Publication Date
Jan 01, 2006
Issue
3
Pages
34–38
Identifiers
PMID: 16889210
Source
Medline
License
Unknown

Abstract

Surgical treatment of complex congenital heart disease under extracorporeal circulation is accompanied by a systemic inflammatory reaction occurring in neonatal infants and babies. There were drastic increases in the concentration of tumor necrosis factor, interleukin-8, neutrophilic elastase and a predominance of a proinflammatory response over an inflammatory one at the warming stages and after administration of protamine sulfate. The rate of an inflammatory response depended on the duration of extracorporeal circulation. Modified ultrafiltration could remove cytokines; however, their concentration in the body remains high. A relationship was found between the course of a postoperative period and the rate of a developing reaction to extracorporeal circulation in the surgical treatment of congenital heart diseases.

Report this publication

Statistics

Seen <100 times