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Inflammatory myofibroblastic tumor of the pancreas in a dog.

Authors
  • Romanucci, Mariarita1
  • Defourny, Sabrina V P1
  • Massimini, Marcella1
  • Bongiovanni, Laura1
  • Aste, Giovanni1
  • Vignoli, Massimo1
  • Febo, Elettra1
  • Boari, Andrea1
  • Della Salda, Leonardo1
  • 1 Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy. , (Italy)
Type
Published Article
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Publication Date
Nov 01, 2019
Volume
31
Issue
6
Pages
879–882
Identifiers
DOI: 10.1177/1040638719879737
PMID: 31585512
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A large, ill-defined, firm, multinodular mass involving the pancreas was confirmed on postmortem examination of a 5-y-old, male Rottweiler that died following acute respiratory distress syndrome, after a period of anorexia and lethargy. Histologically, the mass consisted of plump spindle cells admixed with a variable number of macrophages, lymphocytes, plasma cells, and neutrophils. Foci of coagulative necrosis and hemorrhage were also observed. Spindle cells strongly reacted to antibodies against vimentin, α-smooth muscle actin, and calponin, whereas desmin was expressed only mildly and focally. Pan-cytokeratin, KIT, glial fibrillary acidic protein, and S100 protein were nonreactive. Variable numbers of MAC 387-positive cells, CD3+ lymphocytes, and numerous blood vessels were also detected throughout the mass. Histologic and IHC findings were consistent with a diagnosis of inflammatory myofibroblastic tumor of the pancreas.

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