Affordable Access

Inflammatory manifestations of experimental lymphatic insufficiency.

Authors
Type
Published Article
Journal
PLoS Medicine
1549-1676
Publisher
Public Library of Science
Publication Date
Volume
3
Issue
7
Identifiers
PMID: 16834456
Source
Medline
License
Unknown

Abstract

We have characterized a mouse model of acute, acquired lymphedema using in vivo functional imaging and histopathological correlation. The model closely simulates the volume response, histopathology, and lymphoscintigraphic characteristics of human acquired lymphedema, and the response is accompanied by an increase in the number and size of microlymphatic structures in the lymphedematous cutaneous tissues. Molecular characterization through clustering of genes with known functions provides insights into processes and signaling pathways that compose the acute tissue response to lymph stagnation. Further study of genes identified through this effort will continue to elucidate the molecular mechanisms and lead to potential therapeutic strategies for lymphatic vascular insufficiency.

Statistics

Seen <100 times