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Inflammation and intestinal function: where does it start and what does it mean?

Authors
  • Tappenden, Kelly A
Type
Published Article
Journal
JPEN. Journal of parenteral and enteral nutrition
Publication Date
Jan 01, 2008
Volume
32
Issue
6
Pages
648–650
Identifiers
DOI: 10.1177/0148607108325177
PMID: 18974246
Source
Medline
License
Unknown

Abstract

Various key elements of intestinal function, such as digestion, absorption, and barrier function, are impaired during inflammation. Although intestinal damage associated with inflammation originating within the intestine is well-known, inflammation in distant organs can impair intestinal function, despite normal histological appearance of the impacted intestinal mucosa. Widespread clinical dogma indicating that intestinal dysfunction drives inflammation should be reconsidered based on data indicating that, in many situations, inflammation precedes intestinal damage and appears to be the injurious factor. Finally, various nutrients have been shown to protect and/or repair the intestinal mucosa from the effects of inflammation; therefore, strategies for optimizing the nutrients provided during inflammatory states should be considered.

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