Affordable Access

Access to the full text

Inflammation brakes mitochondrial metabolism in obesity

Authors
  • Tavernarakis, Nektarios1, 2
  • 1 Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece , Heraklion (Greece)
  • 2 University of Crete, Heraklion, Crete, Greece , Heraklion (Greece)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 27, 2020
Volume
21
Issue
10
Pages
1143–1145
Identifiers
DOI: 10.1038/s41590-020-0780-8
Source
Springer Nature
License
Yellow

Abstract

A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

Report this publication

Statistics

Seen <100 times