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Inflammation in atherosclerosis.

Authors
  • Libby, Peter
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Sep 01, 2012
Volume
32
Issue
9
Pages
2045–2051
Identifiers
DOI: 10.1161/ATVBAHA.108.179705
PMID: 22895665
Source
Medline
License
Unknown

Abstract

Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers provided a mechanism whereby risk factors for atherosclerosis can alter arterial biology, and produce a systemic milieu that favors atherothrombotic events. The discovery of the immune basis of allograft arteriosclerosis demonstrated that inflammation per se can drive arterial hyperplasia, even in the absence of traditional risk factors. Inflammation regulates aspects of plaque biology that trigger the thrombotic complications of atherosclerosis. Translation of these discoveries to humans has enabled both novel mechanistic insights and practical clinical advances.

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