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Infectivity, virulence, pathogenicity, host-pathogen interactions of SARS and SARS-CoV-2 in experimental animals: a systematic review.

Authors
  • Sarkar, Jayanta1, 2
  • Guha, Rajdeep3, 4
  • 1 Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, India. , (India)
  • 2 CSIR-Academy of Scientific and Innovative Research, New Delhi, India. , (India)
  • 3 CSIR-Academy of Scientific and Innovative Research, New Delhi, India. [email protected] , (India)
  • 4 Laboratory Animals Facility , CSIR-Central Drug Research Institute , Lucknow, India. [email protected] , (India)
Type
Published Article
Journal
Veterinary Research Communications
Publisher
Springer-Verlag
Publication Date
Nov 01, 2020
Volume
44
Issue
3-4
Pages
101–110
Identifiers
DOI: 10.1007/s11259-020-09778-9
PMID: 32651761
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The outbreak of the SARS-CoV-2 in mainland China with subsequent human to human transmission worldwide had taken up the shape of a devastating pandemic. The ability of the virus to infect multiple species other than humans has currently been reported in experimental conditions. Non-human primates, felines, ferrets, rodents and host of other animals could previously be infected in experimental conditions with SARS-CoV and recently with SARS-CoV-2, both virus using Angiotensin-converting-enzyme 2 receptor for cellular entry. The variations in sequence homology of ACE2 receptor across species is identified as one of the factors determining virulence and pathogenicity in animals. The infection in experimental animals with SARS-CoV or SARS-CoV-2 on most occasions are asymptomatic, however, the virus could multiply within the respiratory tract and extra-pulmonary organs in most of the species. Here, we discuss about the pathogenicity, transmission, variations in angiotensin-converting-enzyme 2 receptor-binding across species and host pathogen interactions of SARS and SARS-CoV-2 in laboratory animals used in research.

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