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Infection of macrophages by Theiler's murine encephalomyelitis virus is highly dependent on their activation or differentiation state.

Authors
Type
Published Article
Journal
Journal of virology
Publication Date
Volume
71
Issue
11
Pages
8864–8867
Identifiers
PMID: 9343249
Source
Medline
License
Unknown

Abstract

Macrophages are the main targets of Theiler's murine encephalomyelitis virus (TMEV) during persistent demyelinating infection of mice. Replication of TMEV in macrophages was previously shown to depend on their activation state. Here, we show that the quality of the serum used for culture drastically influences viral entry in RAW264.7 macrophages.

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