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Infection of human papillomavirus type 18 and p53 codon 72 polymorphism in lung cancer patients from India.

Authors
  • Jain, Neeraj
  • Singh, Vikram
  • Hedau, Suresh
  • Kumar, Suresh
  • Daga, Mradul K
  • Dewan, Richa
  • Murthy, Nandagudi S
  • Husain, Syed A
  • Das, Bhudev C
Type
Published Article
Journal
Chest
Publication Date
Dec 01, 2005
Volume
128
Issue
6
Pages
3999–4007
Identifiers
PMID: 16354872
Source
Medline
License
Unknown

Abstract

HPV detected in a small proportion of lung cancer patients in India demonstrated an exclusive prevalence of HPV type 18, and there was a significantly higher frequency of p53 Arg/Arg genotype when compared to that of control subjects. Observation of a shorter duration of symptoms (< or = 4 months) in as many as 78% (seven of nine stage IV patients) with Arg/Pro genotype may be an indication that lung cancer patients with the heterozygous p53 genotype are more susceptible to early progression.

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