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Infection and atherosclerosis: TLR-dependent pathways

Authors
  • Li, Bowei1
  • Xia, Yuanpeng1
  • Hu, Bo1
  • 1 Tongji Medical College, Huazhong University of Science and Technology,
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Jan 30, 2020
Volume
77
Issue
14
Pages
2751–2769
Identifiers
DOI: 10.1007/s00018-020-03453-7
PMID: 32002588
PMCID: PMC7223178
Source
PubMed Central
Keywords
License
Unknown

Abstract

Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like hyperlipidemia, hypertension, smoking and obesity, emerging evidence suggests that atherosclerosis is a chronic inflammatory disease, suggesting that chronic infection plays an important role in the development of atherosclerosis. Toll-like receptors (TLRs) are the most characteristic members of pattern recognition receptors (PRRs), which play an important role in innate immune mechanism. TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as Chlamydia pneumoniae ( C. pneumoniae ) , periodontal pathogens including Porphyromonas gingivalis ( P. gingivalis ) , Helicobacter pylori ( H. pylori ) and human immunodeficiency virus (HIV). Overall, activation of TLR2 and 4 seems to have a profound impact on infection-related atherosclerosis. This article reviews the role of TLRs in the process of atherosclerosis after C. pneumoniae and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD.

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