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Inefficient CAR-proximal signaling blunts antigen sensitivity

Authors
  • Gudipati, Venugopal1
  • Rydzek, Julian2
  • Doel-Perez, Iago1
  • Gonçalves, Vasco Dos Reis2
  • Scharf, Lydia1, 3
  • Königsberger, Sebastian1, 4
  • Lobner, Elisabeth5
  • Kunert, Renate5
  • Einsele, Hermann2
  • Stockinger, Hannes1
  • Hudecek, Michael2
  • Huppa, Johannes B.1
  • 1 Medical University of Vienna, Vienna, Austria , Vienna (Austria)
  • 2 Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany , Würzburg (Germany)
  • 3 Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden , Stockholm (Sweden)
  • 4 Roche Diagnostics GmbH, Penzberg, Germany , Penzberg (Germany)
  • 5 University of Natural Resources and Life Sciences, Vienna, Austria , Vienna (Austria)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 06, 2020
Volume
21
Issue
8
Pages
848–856
Identifiers
DOI: 10.1038/s41590-020-0719-0
Source
Springer Nature
License
Yellow

Abstract

Huppa and colleagues highlight signaling deficiencies in chimeric antigen receptor (CAR)-modified T cells that limit the efficacy of CAR T cell therapies to target tumors with diminished antigen expression.

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