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Ineffective and prolonged apical contraction is associated with chest pain and ischaemia in apical hypertrophic cardiomyopathy.

Authors
  • Stephenson, Edward1
  • Monney, Pierre2
  • Pugliese, Francesca3
  • Malcolmson, James3
  • Petersen, Steffen E3
  • Knight, Charles3
  • Mills, Peter4
  • Wragg, Andrew3
  • O'Mahony, Constantinos4
  • Sekhri, Neha3
  • Mohiddin, Saidi A5
  • 1 William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Centre at Barts, Queen Mary University of London, London, United Kingdom. , (United Kingdom)
  • 2 Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom; University Hospital of Lausanne (CHUV), Lausanne, Switzerland. , (Switzerland)
  • 3 William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Centre at Barts, Queen Mary University of London, London, United Kingdom; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom. , (United Kingdom)
  • 4 Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom. , (United Kingdom)
  • 5 William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Centre at Barts, Queen Mary University of London, London, United Kingdom; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom. Electronic address: [email protected] , (United Kingdom)
Type
Published Article
Journal
International journal of cardiology
Publication Date
Jan 15, 2018
Volume
251
Pages
65–70
Identifiers
DOI: 10.1016/j.ijcard.2017.09.206
PMID: 29197461
Source
Medline
Keywords
License
Unknown

Abstract

In apical HCM, regional contractile persistence is associated with impaired myocardial perfusion and chest pain. As apical myocardium makes limited contributions to stroke volume, apical contractility is also largely ineffective. Interventions to reduce apical contraction and/or muscle mass are potential therapies for improving symptoms without reducing cardiac output.

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