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Inductive Materials for Regenerative Engineering.

Authors
  • Hosseini, F S1, 2, 3, 4
  • Nair, L S1, 2, 3, 5, 6
  • Laurencin, C T1, 2, 3, 5, 6, 7
  • 1 Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA.
  • 2 Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, USA.
  • 3 Department of Orthopedic Surgery, University of Connecticut Health, Farmington, CT, USA.
  • 4 Department of Skeletal Biology and Regeneration, UConn Health, Farmington, CT, USA.
  • 5 Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
  • 6 Department of Materials Science and Engineering, University of Connecticut, Storrs, CT, USA.
  • 7 Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA.
Type
Published Article
Journal
Journal of dental research
Publication Date
Sep 01, 2021
Volume
100
Issue
10
Pages
1011–1019
Identifiers
DOI: 10.1177/00220345211010436
PMID: 33906507
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Regenerative engineering has pioneered several novel biomaterials to treat critical-sized bone injuries. However, despite significant improvement in synthetic materials research, some limitations still exist. The constraints correlated with the current grafting methods signify a treatment paradigm shift to osteoinductive regenerative engineering approaches. Because of their intrinsic potential, inductive biomaterials may represent alternative approaches to treating critical bone injuries. Osteoinductive scaffolds stimulate stem cell differentiation into the osteoblastic lineage, enhancing bone regeneration. Inductive biomaterials comprise polymers, calcium phosphate ceramics, metals, and graphene family materials. This review will assess the cellular behavior toward properties of inductive materials.

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