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Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde.

Authors
Type
Published Article
Journal
Japanese journal of cancer research : Gann
Publication Date
Volume
79
Issue
8
Pages
917–920
Identifiers
PMID: 3141327
Source
Medline

Abstract

Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor-promoting activity in carcinogenesis in the glandular stomach.

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