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Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.

Authors
  • Biondo, Carmelo
  • Beninati, Concetta
  • Bombaci, Mauro
  • Messina, Luciano
  • Mancuso, Giuseppe
  • Midiri, Angelina
  • Galbo, Roberta
  • Teti, Giuseppe
Type
Published Article
Journal
Infection and immunity
Publication Date
Sep 01, 2003
Volume
71
Issue
9
Pages
5412–5417
Identifiers
PMID: 12933895
Source
Medline
License
Unknown

Abstract

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.

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