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Induction of pancreatic neoplasms by 2,2'-dioxopropyl-N-propylnitrosamine.

Authors
  • Pour, P
  • Althoff, J
  • Krüger, F
  • Schmähl, D
  • Mohr, U
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Sep 01, 1975
Volume
1
Issue
1
Pages
3–6
Identifiers
PMID: 1235057
Source
Medline
License
Unknown

Abstract

A high incidence of pancreatic duct adenomas and carcinomas were induced in Syrian golden hamsters as early as 13 weeks after chronic administration of 2,2'-dioxopropyl-n-propylnitrosamine (DOPN) at a 10 mg/kg dose. In contrast to another pancreatic carcinogen, 2,2'-dihydroxy-propyl-n-propyl-nitrosamine, DOPN induced no tumors of the upper respiratory tract or kidneys, and only a few neoplasms of the lungs and liver.

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