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Induction of synthesis of components of the hydrogen peroxide-generating oxidase during activation of the human monocytic cell line U937 by interferon-gamma.

Authors
  • P W Andrew
  • A K Robertson
  • D B Lowrie
  • A R Cross
  • O T Jones
Publication Date
Nov 15, 1987
Source
PMC
Keywords
License
Unknown

Abstract

Increased amounts of cytochrome b-245 and a 45 kDa polypeptide component of the hydrogen peroxide-generating oxidase were detected in the human monocytic cell line U937 after incubation in interferon-gamma. The time course of increase in cytochrome b-245 paralleled the induction of oxidase activity. Induction of the 45 kDa component had a different time course, having a greater lag before increased amounts were seen.

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