Affordable Access

Induction of Protective Immunity to Listeria monocytogenes by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain

Authors
  • Toshi Nagata
  • Taiki Aoshi
  • Mina Suzuki
  • Masato Uchijima
  • Yeung-Hyen Kim
  • Zhibo Yang
  • Yukio Koide
Publisher
American Society for Microbiology
Publication Date
May 01, 2002
Source
PMC
Keywords
License
Unknown

Abstract

Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by a Listeria Th epitope. Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-γ- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.

Report this publication

Statistics

Seen <100 times