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Induction of Emetic Response to Staphylococcal Enterotoxins in the House Musk Shrew (Suncus murinus)

Authors
  • Dong-Liang Hu
  • Katsuhiko Omoe
  • Yu Shimoda
  • Akio Nakane
  • Kunihiro Shinagawa
Publisher
American Society for Microbiology
Publication Date
Jan 01, 2003
Source
PMC
Keywords
License
Unknown

Abstract

The emetic responses induced by staphylococcal enterotoxin A (SEA), SEB, SEC2, SED, SEE, SEG, SEH, and SEI in the house musk shrew (Suncus murinus) were investigated. SEA, SEE, and SEI showed higher emetic activity in the house musk shrew than the other SEs. SEB, SEC2, SED, SEG, and SEH also induced emetic responses in this animal model but relatively high doses were required. The house musk shrew appears to be a valuable model for studying the mechanisms of emetic reactions caused by SEs.

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