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Induction of nitric oxide synthase in human vascular smooth muscle: interactions between proinflammatory cytokines.

Authors
  • Chester, A H
  • Borland, J A
  • Buttery, L D
  • Mitchell, J A
  • Cunningham, D A
  • Hafizi, S
  • Hoare, G S
  • Springall, D R
  • Polak, J M
  • Yacoub, M H
Type
Published Article
Journal
Cardiovascular research
Publication Date
Jun 01, 1998
Volume
38
Issue
3
Pages
814–821
Identifiers
PMID: 9747450
Source
Medline
License
Unknown

Abstract

We have shown that increased production of nitrite by human vascular tissue in response to cytokines is associated with induction of iNOS as shown at the molecular and protein levels, and further supported by the presence of increased Ca(2+)-independent nitric oxide synthase activity following cytokine stimulation.

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