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Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays

Authors
  • STOLL, L. B.
  • CREMONESI, F. C. A.
  • PIRES, L. T. A.
  • ZUCCHI, T. D.
  • ZUCCHI, T. M. A. D.
Publication Date
Jan 01, 2008
Source
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
Keywords
Language
English
License
Unknown
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Abstract

As a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individu`ally analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/carcinogenic genomic effects of low-dose X-rays.

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