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Induction and management of diabetes mellitus in the pig.

Authors
  • Wilson, J D
  • Dhall, D P
  • Simeonovic, C J
  • Lafferty, K J
Type
Published Article
Journal
The Australian journal of experimental biology and medical science
Publication Date
Dec 01, 1986
Volume
64 ( Pt 6)
Pages
489–500
Identifiers
PMID: 2954529
Source
Medline
License
Unknown

Abstract

Insulin-dependent diabetes mellitus was induced in the pig by pancreatectomy or by administration of intravenous streptozotocin (150 mg/kg). High post-operative morbidity and mortality in the pancreatectomised animals made this method of inducing diabetes unsuitable for animals to be used in long term studies. By contrast, the good clinical state of animals after streptozotocin and the permanence of their diabetes indicated that these animals were suitable for long term studies such as those involving transplantation of pancreatic islet tissue. Techniques designed to facilitate the assessment and management of these animals included placement of an indwelling jugular venous catheter to enable blood samples to be obtained for metabolic studies, denervation of an area on the flank of the animal to enable insulin administration with minimum discomfort and denervation of an ear to enable blood samples to be obtained from the animal for glucose estimation in long term studies.

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