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Induction of lethal mutations in experimental tumours after single and fractionated irradiations in vivo.

Authors
Type
Published Article
Journal
International journal of radiation biology
Publication Date
Volume
74
Issue
1
Pages
119–127
Identifiers
PMID: 9687981
Source
Medline

Abstract

These effects indicate that conventional excision assays of tumour cell viability under-estimate the total lethal damage caused by irradiation and have implications for modelling of the response of tumours to radiotherapy. The effect of fractionation on expression of this type of damage implies the involvement of repair processes. Therefore the repair proficiency may affect the balance between the immediate and delayed reduction of viability in irradiated cells.

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