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Induction of the intermediate pituitary by stress: synthesis and release of a nonopioid form of beta-endorphin.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
227
Issue
4685
Pages
424–426
Identifiers
PMID: 3155575
Source
Medline
License
Unknown

Abstract

beta-Endorphin in the intermediate lobe of the pituitary gland is posttranslationally modified to produce opioid inactive peptides. Whether these are metabolites or biologically relevant products has not been known. It was found that repeated stress induces increased biosynthesis and release of beta-endorphin-like substances from the intermediate lobe of rats and that opioid-inactive N-acetylated beta-endorphin-(1-31) is selectively made and liberated. The possible role of this nonopioid product and the selective release of peptide forms are discussed.

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