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Induction of hepatic drug-metabolizing enzymes by cyclic fatty acid monomers in the rat.

Authors
  • Siess, M H
  • Vernevaut, M F
  • Grandgirard, A
  • Sébédio, J L
Type
Published Article
Journal
Food and Chemical Toxicology
Publisher
Elsevier
Publication Date
Jan 01, 1988
Volume
26
Issue
1
Pages
9–13
Identifiers
PMID: 3126120
Source
Medline
License
Unknown

Abstract

The effects of cyclic monomers on the activities of several drug-metabolizing enzymes were evaluated. Female Wistar rats were fed, for 4 wk, a semi-synthetic diet containing different quantities of cyclic monomers isolated from linseed oil heated at 275 degrees C for 12 hr under nitrogen. Microsomal proteins and cytochrome c were significantly increased in rats fed a diet containing 0.1 or 1% cyclic monomers. Aminopyrine demethylation, a model reaction preferentially induced by phenobarbital, was increased by this treatment. NADPH-cytochrome P-450 reductase was also stimulated. Moreover, ethoxyresorufin deethylation, known to be greatly increased by methylcholanthrene-type inducer was only increased threefold by this treatment. The activity of p-nitrophenol UDP-glucuronosyl transferase decreased while the conjugation of bilirubin was stimulated. These results suggest that cyclic monomers isolated from heated linseed oil show some characteristics of phenobarbital-type inducers.

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