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Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection.

Authors
  • Mannon, R B
  • Roberts, K
  • Ruiz, P
  • Laubach, V
  • Coffman, T M
Type
Published Article
Journal
The Journal of Heart and Lung Transplantation
Publisher
Elsevier
Publication Date
Sep 01, 1999
Volume
18
Issue
9
Pages
819–827
Identifiers
PMID: 10528743
Source
Medline
License
Unknown

Abstract

Rejection of cardiac allografts by iNOS(-/-) mice occurs in a similar fashion to wild-type recipients, with extensive inflammation and proinflammatory cytokine production. While iNOS may play a role in cytokine induction by macrophages, these studies suggest that iNOS is not required for efficient cardiac graft rejection.

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