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Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection.

Authors
Type
Published Article
Journal
The Journal of Heart and Lung Transplantation
1053-2498
Publisher
Elsevier
Publication Date
Volume
18
Issue
9
Pages
819–827
Identifiers
PMID: 10528743
Source
Medline
License
Unknown

Abstract

Rejection of cardiac allografts by iNOS(-/-) mice occurs in a similar fashion to wild-type recipients, with extensive inflammation and proinflammatory cytokine production. While iNOS may play a role in cytokine induction by macrophages, these studies suggest that iNOS is not required for efficient cardiac graft rejection.

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