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Indomethacin versus radiation therapy for heterotopic ossification after hip arthroplasty.

Authors
  • D'Lima, D D
  • Venn-Watson, E J
  • Tripuraneni, P
  • Colwell, C W
Type
Published Article
Journal
Orthopedics
Publication Date
Dec 01, 2001
Volume
24
Issue
12
Pages
1139–1143
Identifiers
PMID: 11770090
Source
Medline
License
Unknown

Abstract

This study compared the efficacy and cost of radiation therapy with indomethacin in the prophylaxis of heterotopic ossification following total hip replacement. Twenty-two patients received a radiation dose of 10 Gy in five fractions, 28 patients 8 Gy in one fraction, and 27 patients 25 mg oral indomethacin three times a day for either 7 or 21 days. Patients at higher risk for heterotopic ossification were more likely to receive radiation therapy than indomethacin. At a mean follow-up of 2 years, there were no differences in failure rates between the high-risk patients treated with radiation and the low-risk patients treated with indomethacin. Currently, the patient-billed cost of radiation is $1400 whereas the cost for indomethacin is approximately $100. Indomethacin appears to be as effective as radiation therapy in patients at low to moderate risk for heterotopic ossification and offers significant cost savings.

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