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Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

Authors
  • Alexey Popov
  • Zeinab Abdullah
  • Claudia Wickenhauser
  • Tomo Saric
  • Julia Driesen
  • Franz-Georg Hanisch
  • Eugen Domann
  • Emma Lloyd Raven
  • Oliver Dehus
  • Corinna Hermann
  • Daniela Eggle
  • Svenja Debey
  • Trinad Chakraborty
  • Martin Krönke
  • Olaf Utermöhlen
  • Joachim L. Schultze
Publisher
American Society for Clinical Investigation
Publication Date
Nov 16, 2006
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. We show in human listeriosis that DCs expressing indoleamine 2,3-dioxygenase (IDO), together with macrophages, are major cellular components of suppurative granulomas in vivo. Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as Bartonella henselae. Reporting on our use of the clinically applied anti–TNF-α antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-α dependent. Repression of IDO therefore might result in exacerbation of granulomatous diseases observed during anti–TNF-α therapy. These findings place IDO+ DCs not only at the intersection of innate and adaptive immunity but also at the forefront of bacterial containment in granulomatous infections.

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