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Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells.

Authors
  • Snyder-Cappione, Jennifer E1
  • Nixon, Douglas F
  • Loo, Christopher P
  • Chapman, Joan M
  • Meiklejohn, Duncan A
  • Melo, Fernando F
  • Costa, Priscilla R
  • Sandberg, Johan K
  • Rodrigues, Denise S
  • Kallas, Esper G
  • 1 Division of Experimental Medicine, University of California, San Francisco, CA 94143, USA.
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
May 01, 2007
Volume
195
Issue
9
Pages
1361–1364
Identifiers
PMID: 17397008
Source
Medline
License
Unknown

Abstract

Mycobacterium tuberculosis (MTB) is a leading cause of mortality worldwide from an infectious agent. Natural killer T (NKT) cells recognize mycobacterial antigens and contribute to anti-MTB immunity in mouse models. NKT cells were measured in subjects with pulmonary tuberculosis, MTB-exposed individuals, and healthy controls. NKT cell levels are selectively lower in peripheral blood mononuclear cells from individuals with pulmonary tuberculosis than in both MTB-exposed subjects and healthy control subjects. This apparent loss of NKT cells from the peripheral blood is sustained during the 6 months after the initiation of MTB treatment. These findings indicate that NKT cells may be an important component of antituberculosis immunity.

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